Subjective feelings of familiarity associated with a stimulus tend to be strongest when specific information about the previous encounter with the stimulus is difficult to retrieve . Recognizing: The judgment of previous occurrence. Psychological Review, 87, 252–271.]). When a stimulus has been encountered previously and the circumstances of the encounter cannot be recollected, additional cognitive resources may be directed toward recollection processes; this resource allocation is accompanied by autonomic arousal [Dawson, M. E., Filion, D. L., & Schell, A. M. . (...) Is elicitation of the autonomic orienting response associated with allocation of processing resources?. Psychophysiology, 26, 560–572]. One easily measurable index of autonomic arousal is the skin conductance response . In the present study, participants studied lists of words and then gave recognition ratings to briefly displayed and masked studied and nonstudied test words while their SCRs were monitored. Results revealed a relationship between recognition ratings and the temporal characteristics of the SCR, supporting the idea that feelings of familiarity are indeed “feelings” in that they stem from autonomic arousal associated with cognitive resource allocation. (shrink)

Rare copy number variants have a prominent role in the aetiology of schizophrenia and other neuropsychiatric disorders. Substantial risk for schizophrenia is conferred by large CNVs at several loci, including microdeletions at 1q21.1, 3q29, 15q13.3 and 22q11.2 and microduplication at 16p11.2. However, these CNVs collectively account for a small fraction of cases, and the relevant genes and neurobiological mechanisms are not well understood. Here we performed a large two-stage genome-wide scan of rare CNVs and report the significant association of copy (...) number gains at chromosome 7q36.3 with schizophrenia. Microduplications with variable breakpoints occurred within a 362-kilobase region and were detected in 29 of 8,290 patients versus 2 of 7,431 controls in the combined sample. All duplications overlapped or were located within 89 kilobases upstream of the vasoactive intestinal peptide receptor gene VIPR2. VIPR2 transcription and cyclic-AMP signalling were significantly increased in cultured lymphocytes from patients with microduplications of 7q36.3. These findings implicate altered vasoactive intestinal peptide signalling in the pathogenesis of schizophrenia and indicate the VPAC2 receptor as a potential target for the development of new antipsychotic drugs. © 2011 Macmillan Publishers Limited. All rights reserved. (shrink)

In Alabaster v. Barclays Bank plc and Secretary of State for Social Security (No. 2: [2005] E.W.C.A Civ. 508, [2005] I.R.L.R. 576.) Michelle Alabaster won a grand total of £204.53 (plus £65.86 interest) after eight years of litigation, which included two visits to the Court of Appeal and one to the European Court of Justice. This marathon resulted from the sex discrimination which Alabaster had alleged in relation to the calculation of her Statutory Maternity Pay (S.M.P.) whilst she was pregnant (...) 10 years earlier. The technicalities of the statutory schemes involved should not be allowed to disguise the important principle which finally emerges in the Court of Appeal and which underlines one of the longstanding criticisms of the equality legislation, namely the requirement that a woman must compare herself with a man in order to establish unlawful sex discrimination. (shrink)

Obstructive sleep apnea (OSA) severely impacts sleep and has long-term health consequences. Treating sleep apnea with continuous positive airway pressure (CPAP) not only relieves obstructed breathing, but also improves sleep. CPAP improves sleep by reducing apnea-induced awakenings. CPAP may also improve sleep by enhancing features of sleep architecture assessed with electroencephalography (EEG) that maximize sleep depth and neuronal homeostasis, such as the slow oscillation and spindle EEG activity, and by reducing neurophysiological arousal during sleep (i.e., beta EEG activity). We examined (...) cross-sectional differences in quantitative EEG characteristics of sleep, assessed with power spectral analysis, in 29 adults with type 2 diabetes treated with CPAP and 24 adults undergoing SHAM CPAP treatment (total n = 53). We then examined changes in spectral characteristics of sleep as the SHAM group crossed over to active CPAP treatment (n = 19). Polysomnography (PSG) from the CPAP titration night was used for the current analyses. Analyses focused on EEG frequencies associated with sleep maintenance and arousal. These included the slow oscillation (0.5–1 Hz), sigma activity (12–16 Hz, spindle activity), and beta activity (16–20 Hz) in F3, F4, C3, and C4 EEG channels. Whole night non-rapid eye movement (NREM) sleep and the first period of NREM spectral activity were examined. Age and sex were included as covariates. There were no group differences between CPAP and SHAM in spectral characteristics of sleep architecture. However, SHAM cross-over to active CPAP was associated with an increase in relative 12–16 Hz sigma activity across the whole night and a decrease in average beta activity across the whole night. Relative slow oscillation power within the first NREM period decreased with CPAP, particularly for frontal channels. Sigma and beta activity effects did not differ by channel. These findings suggest that CPAP may preferentially enhance spindle activity and mitigate neurophysiological arousal. These findings inform the neurophysiological mechanisms of improved sleep with CPAP and the utility of quantitative EEG measures of sleep as a treatment probe of improvements in neurological and physical health with CPAP. (shrink)

Merleau-Ponty, la passivité et la scienceJe soutiens qu’il y a plus en jeu dans l’intérêt de Merleau-Ponty pour la science qu’une simple dialectique entre disciplines. C’est parce que son évolutionméthodologique le conduit à trouver dans la science un moyen spécifique d’approfondir ses recherches ontologiques, que celle-ci hante de plus en plus sa philosophie. En effet, dans le chapitre « champ phénoménal » de la Phénoménologie de la perception, il est possible de rapprocher certains aspects de son défi méthodologique et l’idée (...) selon laquelle la philosophie tient son origine d’une conscience réflexive, active et autonome dans son ensemble. Je lie cela aux problèmes de la passivité de telle sorte que la science apparaisse comme une façon de saisir la réflexion non pas comme autonome, mais comme une opération du champ phénomenal, comme réflexion radicale. Grâce à l’analyse critique des recherches récentes sur le génome, je montre ensuite commentl’embryologie peut nous aider à conceptualiser la vie comme un champ phénoménal, c’est-à-dire comme un champ qui engendre ce même genre d’opérations qui caractérisent aussi la phénoménalité. Cela nous conduit à voir la phénomenologie non plus comme une réflexion de survol sur les phénomènes, mais plutôt comme une réflexion radicale qui se realise à travers un phénoménalité plus « ancienne », qui appartient à la vie ellemême. Cela ouvre également des perspectives sur quelques problèmes difficiles de la dernière philosophie de Merleau-Ponty; ceux-ci sont abordés d’une manière nouvelle, grâce au rapprochement de sa première philosophie et de la science actuelle.Merleau-Ponty, la passività e la scienzaRitengo che, nell’interesse che Merleau-Ponty rivolge alla scienza, vi sia in gioco qualcosa di più del semplice confronto dialettico con un’altra disciplina. Il motivo è che il suo impegno metodologico finisce per individuare nella scienza una speciale risorsa per l’indagine di quelle profonde questioni ontologiche che investono in modo crescente la sua filosofia. Intendo argomentare tale ipotesi, connettendo dei passi del capitolo di Fenomenologia della percezione “Il campo fenomenico” con la sua sfida metodologica all’idea che la filosofia abbia inizio da una coscienza riflessiva autonoma e interamente attiva. Collego questo alle questioni della passività in un modo che rivela la scienza come una potenziale risorsa per comprendere la riflessione non come autonoma, bensì in quanto operazione di e nel campo fenomenico – come riflessione radicale. Poi, attraverso un’analisi critica dei risultati recenti riguardanti il DNA regolatore, mostrocome l’attuale embriologia può aiutarci a concettualizzare la vita come un campo fenomenico che implicitamente produce i tipi di operazioni rivelatrici distintive della fenomenalità. Questo ci permette di collocare la fenomenologia non semplicemente come una riflessione dall’alto sui fenomeni, ma come una riflessione radicale che opera grazie ad una “più antica” fenomenalità della vita. Questo ci fornisce degli spunti su alcune difficili questioni nella filosofia dell’ultimo Merleau-Ponty, suggerendo un nuovo percorso che giunga a queste combinando il primo periodo della sua filosofia con la scienza recente. (shrink)

Merleau-Ponty, la passivité et la scienceJe soutiens qu’il y a plus en jeu dans l’intérêt de Merleau-Ponty pour la science qu’une simple dialectique entre disciplines. C’est parce que son évolutionméthodologique le conduit à trouver dans la science un moyen spécifique d’approfondir ses recherches ontologiques, que celle-ci hante de plus en plus sa philosophie. En effet, dans le chapitre « champ phénoménal » de la Phénoménologie de la perception, il est possible de rapprocher certains aspects de son défi méthodologique et l’idée (...) selon laquelle la philosophie tient son origine d’une conscience réflexive, active et autonome dans son ensemble. Je lie cela aux problèmes de la passivité de telle sorte que la science apparaisse comme une façon de saisir la réflexion non pas comme autonome, mais comme une opération du champ phénomenal, comme réflexion radicale. Grâce à l’analyse critique des recherches récentes sur le génome, je montre ensuite commentl’embryologie peut nous aider à conceptualiser la vie comme un champ phénoménal, c’est-à-dire comme un champ qui engendre ce même genre d’opérations qui caractérisent aussi la phénoménalité. Cela nous conduit à voir la phénomenologie non plus comme une réflexion de survol sur les phénomènes, mais plutôt comme une réflexion radicale qui se realise à travers un phénoménalité plus « ancienne », qui appartient à la vie ellemême. Cela ouvre également des perspectives sur quelques problèmes difficiles de la dernière philosophie de Merleau-Ponty; ceux-ci sont abordés d’une manière nouvelle, grâce au rapprochement de sa première philosophie et de la science actuelle.Merleau-Ponty, la passività e la scienzaRitengo che, nell’interesse che Merleau-Ponty rivolge alla scienza, vi sia in gioco qualcosa di più del semplice confronto dialettico con un’altra disciplina. Il motivo è che il suo impegno metodologico finisce per individuare nella scienza una speciale risorsa per l’indagine di quelle profonde questioni ontologiche che investono in modo crescente la sua filosofia. Intendo argomentare tale ipotesi, connettendo dei passi del capitolo di Fenomenologia della percezione “Il campo fenomenico” con la sua sfida metodologica all’idea che la filosofia abbia inizio da una coscienza riflessiva autonoma e interamente attiva. Collego questo alle questioni della passività in un modo che rivela la scienza come una potenziale risorsa per comprendere la riflessione non come autonoma, bensì in quanto operazione di e nel campo fenomenico – come riflessione radicale. Poi, attraverso un’analisi critica dei risultati recenti riguardanti il DNA regolatore, mostrocome l’attuale embriologia può aiutarci a concettualizzare la vita come un campo fenomenico che implicitamente produce i tipi di operazioni rivelatrici distintive della fenomenalità. Questo ci permette di collocare la fenomenologia non semplicemente come una riflessione dall’alto sui fenomeni, ma come una riflessione radicale che opera grazie ad una “più antica” fenomenalità della vita. Questo ci fornisce degli spunti su alcune difficili questioni nella filosofia dell’ultimo Merleau-Ponty, suggerendo un nuovo percorso che giunga a queste combinando il primo periodo della sua filosofia con la scienza recente. (shrink)

Since the war there has been a revival of interest in the idea of justice and its relation to law. The main contributions have come from the side of jurisprudence among which may be mentioned Sir Carleton Kemp Allen, Aspects of Justice ; Potter, The Quest of Justice ; Friedmann, Legal Theory ; Stone, Province and Function of Law ; Paton, Textbook of Jurisprudence ; Goodhart, English Law and the Moral Law ; H. L. Hart, The Concept of Law ; (...) E. Dowrick, Justice According to English Common Lawyers ; there have also appeared English translations of important continental contributions, such as the translation by Campbell of Del Vecchio's Justice ; by C. D. Broad of Axel Hägerströms's Inquiries into the Nature of Law and Morals and the work by Alf Ross On Law and Justice. (shrink)

Le chiasme de l’être: une exploration de l’ontologie du sens de Merleau-PontyLa question de l’ontologie inclut celle de savoir comment un être se détermine et acquiert son sens, autrement dit comment il instaure sa différenciation par desorientations, des significations et des différences en général. Cette étude explore l’idée que le sens d’un être provient d’une « chiralité ontologique », c’est-à-dire d’un type de différence ontologique présentant un apparentement caractéristique de ses deux côtés droit et gauche. L’étude montre tout d’abord comment (...) l’ontologie merleau-pontienne de la réversibilité conduit à la question de la chiralité. On fait ensuite entrer dans la discussion des résultats obtenus dans les domaines de la chimie, de la biologie et de la géométrie, pour mieux mettre en lumière l’importance des différences en chiralité et pour élaborer une définition de la « chiralité ontologique » en étroite liaison avec l’ontologie du sens.Il chiasma dell’essere: un’esplorazione dell’ontologia del senso merleau-pontianaIl problema dell’ontologia include il problema di come l’essere sia determinato e acquisisca senso, acquisisca cioè gli orientamenti, i significati, tutte quelle differenze che fanno la differenza. Questo saggio esplora il pensiero secondo il quale il senso dell’essere deriva da una ‘chiralità ontologica,’ una sorta di differenza ontologica con caratteristiche affini alle differenze fra le mani destra e sinistra. Il testo illustra in primo luogo come l’ontologia merleau-pontyana della reversibilità porti alle questioni della chiralità. I risultati della ricerca attuale, in chimica, biologia e geometria sono poi discussi per illuminare l’importanza delle differenze chirali e per sviluppare una definizione della chiralità ontologica che si connette ad una ontologia del senso. (shrink)

Le chiasme de l’être: une exploration de l’ontologie du sens de Merleau-PontyLa question de l’ontologie inclut celle de savoir comment un être se détermine et acquiert son sens, autrement dit comment il instaure sa différenciation par desorientations, des significations et des différences en général. Cette étude explore l’idée que le sens d’un être provient d’une « chiralité ontologique », c’est-à-dire d’un type de différence ontologique présentant un apparentement caractéristique de ses deux côtés droit et gauche. L’étude montre tout d’abord comment (...) l’ontologie merleau-pontienne de la réversibilité conduit à la question de la chiralité. On fait ensuite entrer dans la discussion des résultats obtenus dans les domaines de la chimie, de la biologie et de la géométrie, pour mieux mettre en lumière l’importance des différences en chiralité et pour élaborer une définition de la « chiralité ontologique » en étroite liaison avec l’ontologie du sens.Il chiasma dell’essere: un’esplorazione dell’ontologia del senso merleau-pontianaIl problema dell’ontologia include il problema di come l’essere sia determinato e acquisisca senso, acquisisca cioè gli orientamenti, i significati, tutte quelle differenze che fanno la differenza. Questo saggio esplora il pensiero secondo il quale il senso dell’essere deriva da una ‘chiralità ontologica,’ una sorta di differenza ontologica con caratteristiche affini alle differenze fra le mani destra e sinistra. Il testo illustra in primo luogo come l’ontologia merleau-pontyana della reversibilità porti alle questioni della chiralità. I risultati della ricerca attuale, in chimica, biologia e geometria sono poi discussi per illuminare l’importanza delle differenze chirali e per sviluppare una definizione della chiralità ontologica che si connette ad una ontologia del senso. (shrink)

Le chiasme de l’être: une exploration de l’ontologie du sens de Merleau-PontyLa question de l’ontologie inclut celle de savoir comment un être se détermine et acquiert son sens, autrement dit comment il instaure sa différenciation par desorientations, des significations et des différences en général. Cette étude explore l’idée que le sens d’un être provient d’une « chiralité ontologique », c’est-à-dire d’un type de différence ontologique présentant un apparentement caractéristique de ses deux côtés droit et gauche. L’étude montre tout d’abord comment (...) l’ontologie merleau-pontienne de la réversibilité conduit à la question de la chiralité. On fait ensuite entrer dans la discussion des résultats obtenus dans les domaines de la chimie, de la biologie et de la géométrie, pour mieux mettre en lumière l’importance des différences en chiralité et pour élaborer une définition de la « chiralité ontologique » en étroite liaison avec l’ontologie du sens.Il chiasma dell’essere: un’esplorazione dell’ontologia del senso merleau-pontianaIl problema dell’ontologia include il problema di come l’essere sia determinato e acquisisca senso, acquisisca cioè gli orientamenti, i significati, tutte quelle differenze che fanno la differenza. Questo saggio esplora il pensiero secondo il quale il senso dell’essere deriva da una ‘chiralità ontologica,’ una sorta di differenza ontologica con caratteristiche affini alle differenze fra le mani destra e sinistra. Il testo illustra in primo luogo come l’ontologia merleau-pontyana della reversibilità porti alle questioni della chiralità. I risultati della ricerca attuale, in chimica, biologia e geometria sono poi discussi per illuminare l’importanza delle differenze chirali e per sviluppare una definizione della chiralità ontologica che si connette ad una ontologia del senso. (shrink)

Movement is crucial to Merleau-Ponty’s effort to comprehend sense, meaning as generated within being. This requires a new concept of movement, not as a dislocation within an already determinate space- or time- frame, but as a deeper, more fundamental change that first engenders space and time as determinate contexts in which movement can follow a sensible course. This poses a novel challenge: conceptualizing determinate space and time as contingently arising from a deeper sort of change, which I call templacement. I (...) address this challenge by turning to the Mexica/Aztecs because the most basic term of their ontology is motion-change, and it is obvious to them that motion-change does not occur in an abstract space-time container. Instead, time-place is woven out of ‘prior’ motion-change. This study leads to a deeper lesson for phenomenology, regarding ‘obvious’ presuppositions about what time and philosophy obviously are – and how these presuppositions go hand in hand.La question du mouvement est cruciale dans l’effort de Merleau-Ponty pour comprendre le sens, la signification telle qu’elle se produit dans l’être. Cela requiert un nouveau concept du mouvement, qui n’est pas compris comme un déplacement dans un cadre spatial – ou temporel – prédéterminé, mais plutôt comme un changement plus profond et fondamental, qui, avant tout, produit l’espace et le temps comme des contextes déterminés dans lesquels le mouvement peut suivre un cours sensible. Cela pose un nouveau défi : conceptualiser un espace et un temps déterminés qui résulteraient, de manière contingente, d’un type de changement plus profond, que j’appellerai templacement. Je lance ce défi en me tournant vers les Mexicas/Aztèques parce que le terme le plus élémentaire de leur ontologie est le mouvement-changement, et il est naturel pour eux que le mouvement-changement n’ait pas lieu dans un conteneur spatio-temporel abstrait. Au contraire, le temps-lieu est tissé sans mouvement-changement « préalable ». Cette recherche conduit à un enseignement encore plus profond pour la phénoménologie, concernant au sujet des présupposition “évidentes” sur le temps et sur la philosophie, et elle nous montre aussi comment ces présuppositions sont étroitement liées.Il movimento è un elemento cruciale nello sforzo di Merleau-Ponty di comprendere il senso, il significato in quanto generato all’interno dell’essere. Questo sforzo richiede un nuovo concetto di movimento, da intendere non come movimento-spostamento nell’ambito di una cornice spazio-temporale predefinita, ma come più profondo e più fondamentale mutamento che inaugura lo spazio e il tempo, in quanto contesti nei quali il movimento stesso può esprimere una traiettoria dotata di senso. Si pone quindi una nuova sfida: quella di concettualizzare lo spazio e il tempo come generati da una forma più radicale di mutamento, che propongo di definire templacement. Per affrontare questa sfida, mi rivolgo ai Mexica/Aztechi poiché il termine più basilare della loro ontologia è quello del moto-mutamento, e poiché essi ritengono ovvio che questo moto-mutamento non si verifichi all’interno di un contenitore spazio-temporale astratto: al contrario, lo spazio-tempo è per loro un intreccio che risulta da un moto-mutamento “precedente”. Questo studio permette di ricavare una lezione più profonda per la fenomenologia, che concerne le sue “ovvie” presupposizioni riguardo a che cosa siano “ovviamente” il tempo e la filosofia – e a come queste presupposizioni siano strettamente connesse. (shrink)

When word pairs having a familiar order are sequentially flashed on a computer in their non-familiar order, , observers have a strong phenomenology of seeing them in familiar order . Reversal errors remained frequent even when participants obtained perceptual experience of reverse-display items by beginning with a block of longer-duration trials. A forced-choice order-detection procedure reduced but did not eliminate reversal errors, showing that “fast pairs” is a robust perceptual illusion. Even adjective + noun pairs showed reversal errors, and reversal (...) errors increased with the log frequency of the word pair, consistent with a strong role for statistical processing at the level of multi-word units. (shrink)

Education, by B. H. Streeter.--Marriage, by K. E. Kirk.-- Patriotism, by J. P. R. Maud.--Social inequalities, by C. R. Morris.--Earning and spending, by R. L. Hall.--Gambling, by R. C. Mortimer.--Ethics and religion, by J. S. Bezzant.

Gregory S. Kavka was a prominent and influential figure in contemporary moral and political philosophy. The essays in this volume are concerned with fundamental issues of rational commitment and social justice to which Kavka devoted his work as a philosopher. The essays take Kavka's work as a point of departure and seek to advance the respective debates. The topics include: the relationship between intention and moral action as part of which Kavka's famous 'toxin puzzle' is a focus of discussion, the (...) nature of deterrence, the rationality of morals, contractarian ethics, and the contemporary relevance of Hobbes' political thought. Incorporating important philosophical statements of problems and fresh contributions to the ongoing debate about rational intention this volume will interest not just philosophers but also political scientists and economists. (shrink)

The current article aims to provide an up-to-date synopsis of available techniques to study affect dynamics using intensive longitudinal data. We do so by introducing the following eight dichotomies that help elucidate what kind of data one has, what process aspects are of interest, and what research questions are being considered: single- versus multiple-person data; univariate versus multivariate models; stationary versus nonstationary models; linear versus nonlinear models; discrete time versus continuous time models; discrete versus continuous variables; time versus frequency domain; (...) and modeling the process versus computing descriptives. In addition, we discuss what we believe to be the most urging future challenges regarding the modeling of affect dynamics. (shrink)

Introduction.--Biographical notes.--General analysis of knowledge and the act.--Perceptual and manipulatory phases of the act.--Cosmology.--Value and the act.--Supplementary essays.